The COX6B1 Polyclonal Antibody (CAB12425) is specifically designed for research involving COX6B1, a protein component of cytochrome c oxidase, an important enzyme in the electron transport chain of mitochondria. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By binding to the COX6B1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal tool for studies in mitochondrial biology and related fields.COX6B1 is a crucial subunit of cytochrome c oxidase, which plays a pivotal role in the production of ATP, the energy currency of cells. Dysfunction of this enzyme complex has been linked to various human diseases, including mitochondrial disorders and neurodegenerative conditions.
Research on COX6B1 is therefore essential for understanding the mechanisms underlying these diseases and developing potential therapeutic interventions aimed at restoring mitochondrial function.The COX6B1 Polyclonal Antibody is a valuable asset for scientists studying mitochondrial biology and its implications in health and disease. Its high specificity and sensitivity make it a reliable tool for investigating the role of COX6B1 in cellular metabolism, energy production, and mitochondrial dysfunction. By utilizing this antibody in their research, scientists can gain valuable insights into the molecular mechanisms governing mitochondrial function and its relevance to human health.
Product Name:
COX6B1 Rabbit Polyclonal Antibody
SKU:
CAB12425
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-86 of human COX6B1 (NP_001854.1).
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.
Purification Method:
Affinity purification
Gene ID:
1340
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using COX6B1 antibody (CAB12425) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
