The COX6A1 Polyclonal Antibody (CAB3798) is a valuable tool for researchers studying the cytochrome c oxidase subunit 6A1 (COX6A1) protein. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the COX6A1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in biochemistry and mitochondrial research.COX6A1 is a subunit of the cytochrome c oxidase complex, which plays a crucial role in the electron transport chain and ATP production in mitochondria.
Dysregulation of COX6A1 has been implicated in various diseases, including metabolic disorders and neurodegenerative conditions. Therefore, understanding the function and expression of COX6A1 is essential for unraveling the mechanisms underlying these pathologies and developing targeted therapeutic strategies.Overall, the COX6A1 Polyclonal Antibody (CAB3798) offers researchers a reliable tool for investigating the role of COX6A1 in cellular metabolism and mitochondrial function, ultimately advancing our knowledge of mitochondrial biology and its implications for human health.
Product Name:
COX6A1 Rabbit Polyclonal Antibody
SKU:
CAB3798
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-109 of human COX6A1 (NP_004364.2).
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented.
Purification Method:
Affinity purification
Gene ID:
1337
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using COX6A1 Rabbit pAb (CAB3798) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
