The Cox19 Polyclonal Antibody (PACO22039) is a valuable tool for research involving Cox19, a protein involved in the assembly of cytochrome c oxidase, a key enzyme in the mitochondrial respiratory chain. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blotting.Cox19 plays a crucial role in the biogenesis of cytochrome c oxidase, which is essential for cellular respiration and energy production. Dysregulation of Cox19 has been linked to mitochondrial dysfunction and various diseases, making it an important target for research in mitochondrial biology and mitochondrial disorders.
This antibody binds specifically to Cox19 protein, allowing for detection and analysis in different cell types and tissues. Its high specificity and sensitivity make it an ideal tool for studying the function and regulation of Cox19 in normal physiology and disease settings. Researchers in the fields of biochemistry, cell biology, and mitochondrial biology will find this antibody valuable for their studies on mitochondrial function and dysfunction.
Antibody Name:
COX19 Antibody (PACO22039)
Antibody SKU:
PACO22039
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human COX19.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using COX19 antibody.
Background:
May be required for the assembly of mitochondrial cytochrome c oxidase By similarity.
Synonyms:
Cytochrome c oxidase assembly protein COX19; Hcox19; COX19;
UniProt Protein Function:
COX19: May be required for the assembly of mitochondrial cytochrome c oxidase. Belongs to the COX19 family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 7p22.3Cellular Component: cytoplasm; mitochondrial intermembrane space; cytosolBiological Process: aerobic respiration; mitochondrial respiratory chain complex IV assembly
UniProt Protein Details:
NCBI Summary:
COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metal transport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008]
