The COX19 Polyclonal Antibody (PAC013917) is a valuable tool for researchers studying COX19, a protein involved in the assembly of cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.COX19 is essential for the proper function of COX, which is responsible for generating ATP, the cell's energy source. Mutations in COX19 have been associated with mitochondrial complex IV deficiency, a condition that can lead to severe neurological and muscular symptoms.
Therefore, studying COX19 is crucial for understanding mitochondrial function and its impact on human health.By targeting COX19, researchers can investigate its role in mitochondrial biogenesis and energy production, as well as its potential as a therapeutic target for mitochondrial disorders. The COX19 Polyclonal Antibody provides a reliable tool for detecting and analyzing COX19 expression in various cell types, making it a valuable asset for research in mitochondrial biology and related fields.
Antibody Name:
COX19 Antibody (PACO13917)
Antibody SKU:
PACO13917
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:10000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human COX19
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO13917(COX19 Antibody) at dilution 1/50. (Original magnification: x200).
The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO13917(COX19 Antibody) at dilution 1/50. (Original magnification: x200).
Background:
COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metal transport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain.
Synonyms:
COX19 cytochrome c oxidase assembly factor
UniProt Protein Function:
COX19: May be required for the assembly of mitochondrial cytochrome c oxidase. Belongs to the COX19 family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 7p22.3Cellular Component: cytoplasm; mitochondrial intermembrane space; cytosolBiological Process: aerobic respiration; mitochondrial respiratory chain complex IV assembly
UniProt Protein Details:
NCBI Summary:
COX19 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox19 protein may play a role in metal transport to the mitochondrial intermembrane space and assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 [PubMed 16212937]).[supplied by OMIM, Mar 2008]
