The COX18 Polyclonal Antibody (PACO08545) is a valuable tool for researchers studying COX18, a protein involved in the biogenesis of cytochrome c oxidase (COX), a key enzyme in the mitochondrial respiratory chain. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.COX18 plays a crucial role in the assembly of COX, which is essential for cellular energy production through oxidative phosphorylation. Dysregulation of COX18 has been linked to mitochondrial diseases and disorders impacting energy metabolism.
Therefore, studying the function and regulation of COX18 is important for understanding mitochondrial function and developing treatments for related conditions.With its ability to specifically bind to COX18, this antibody enables accurate detection and analysis of the protein in various cell types. Its utility in immunology and mitochondrial biology research makes it a valuable asset for scientists investigating mitochondrial disorders, metabolic diseases, and other conditions related to mitochondrial dysfunction.
COX18 cytochrome c oxidase assembly homolog (S. cerevisiae);COX18;COX18HS;FLJ38991;MGC126733 ;
UniProt Protein Function:
COX18: Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space. Belongs to the OXA1/ALB3/YidC family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Mitochondrial; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 4q13.3Cellular Component: integral to mitochondrial inner membraneMolecular Function: protein transporter activityBiological Process: protein transport; protein insertion into mitochondrial membrane; respiratory chain complex IV assembly
UniProt Protein Details:
NCBI Summary:
This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase assembly and activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
