The Cox17 Antibody (PACO8544) is a polyclonal antibody specifically designed for research involving Cox17, a protein involved in copper transport and mitochondrial function. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications such as Western blot and immunofluorescence.Cox17 is a key player in copper homeostasis within the cell, particularly within the mitochondria where it is involved in the delivery of copper to cytochrome c oxidase, an essential enzyme in the electron transport chain. Dysregulation of Cox17 has been linked to disorders of copper metabolism and mitochondrial dysfunction, making it a crucial target for research in areas such as neurodegenerative diseases, metabolic disorders, and mitochondrial disorders.
By using the Cox17 Antibody in experiments, researchers can effectively detect and analyze Cox17 protein levels in various cell types and tissues, providing valuable insights into the role of Cox17 in cellular copper homeostasis and mitochondrial function. This antibody is an essential tool for studies in biochemistry, cell biology, and mitochondrial research, offering a deeper understanding of the mechanisms underlying these important cellular processes.
COX17 cytochrome c oxidase assembly homolog (S. cerevisiae);COX17;MGC104397;MGC117386 ;
UniProt Protein Function:
COX17: Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX. Belongs to the COX17 family.Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylationChromosomal Location of Human Ortholog: 3q13.33Cellular Component: mitochondrion; cytoplasm; mitochondrial intermembrane spaceMolecular Function: copper ion binding; copper chaperone activityBiological Process: generation of precursor metabolites and energy; heart development; brain development; copper ion transport
UniProt Protein Details:
NCBI Summary:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]
