The Cox17 Polyclonal Antibody (PACO00630) is a valuable tool for researchers studying the Cox17 protein, which plays a critical role in copper ion binding and transport within the cell. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding to the Cox17 protein, researchers can accurately detect and analyze its expression in various cell types, making it ideal for studies in biochemistry and cellular biology.Cox17 is essential for proper mitochondrial function, as it is involved in the delivery of copper ions to cytochrome c oxidase, a key enzyme in the electron transport chain.
Dysregulation of Cox17 has been linked to diseases such as mitochondrial disorders and neurodegenerative diseases. Therefore, understanding the role of Cox17 in copper homeostasis is crucial for developing targeted therapies for these conditions.Overall, the Cox17 Polyclonal Antibody is a valuable tool for researchers seeking to delve deeper into the molecular mechanisms governing copper transport and mitochondrial function, with potential implications for the treatment of various human diseases.
Antibody Name:
COX17 Antibody
Antibody SKU:
PACO00630
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the N-terminal region of human COX17.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
COX17; Cytochrome c oxidase copper chaperone
UniProt Protein Function:
COX17: Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX. Belongs to the COX17 family.Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylationChromosomal Location of Human Ortholog: 3q13.33Cellular Component: mitochondrion; cytoplasm; mitochondrial intermembrane spaceMolecular Function: copper ion binding; copper chaperone activityBiological Process: generation of precursor metabolites and energy; heart development; brain development; copper ion transport
UniProt Protein Details:
NCBI Summary:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]
