The COX16 Antibody (PAC013906) is a powerful tool for researchers studying COX16, a key protein involved in the assembly of cytochrome c oxidase (COX), a crucial enzyme in the mitochondrial respiratory chain. This polyclonal antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for use in Western blot and immunohistochemistry applications. By targeting the COX16 protein, researchers can accurately detect and analyze its expression in various cell types, aiding in investigations related to mitochondrial function and energy production.
COX16 is essential for the biogenesis of COX, which is responsible for the final step in the electron transport chain, generating ATP for cellular energy production. Dysregulation of COX16 has been implicated in various mitochondrial disorders and diseases, making it a key target for research in the fields of biochemistry, genetics, and neurodegenerative disorders. By understanding the role of COX16 in mitochondrial function, researchers can uncover new insights into disease mechanisms and potential therapeutic strategies targeting mitochondrial dysfunction.
Antibody Name:
COX16 Antibody (PACO13906)
Antibody SKU:
PACO13906
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:500-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human COX16
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO13906(COX16 Antibody) at dilution 1/50. (Original magnification: x200).
The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO13906(COX16 Antibody) at dilution 1/50. (Original magnification: x200).
Background:
This protein is encoded by COX16, corresponding to the previously uncharacterized open reading frame YJL003w of the yeast genome. COX16 was identified in studies of COX-deficient mutants previously assigned to complementation group G22 of a collection of yeast pet mutants. To determine its location, Cox16p was tagged with a Myc epitope at the C terminus.
Synonyms:
COX16 cytochrome c oxidase assembly homolog (S. cerevisiae)
UniProt Protein Function:
COX16: Belongs to the COX16 family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 14q24.2Cellular Component: mitochondrial membrane; integral to membrane
