The COX15 Polyclonal Antibody (CAB14665) is a valuable tool for researchers studying the COX15 protein, a key player in the assembly of cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.COX15 is essential for the proper functioning of the electron transport chain and defects in this protein have been linked to a range of mitochondrial disorders. The COX15 Polyclonal Antibody allows for the detection and analysis of COX15 protein levels in various cell types, providing insights into mitochondrial function and potential implications for diseases related to mitochondrial dysfunction.
Research into COX15 is crucial for understanding the molecular mechanisms underlying mitochondrial disorders and developing targeted therapies for these conditions. By using the COX15 Polyclonal Antibody, researchers can further unravel the role of COX15 in mitochondrial function, paving the way for advancements in the treatment of mitochondrial-related diseases.
Product Name:
COX15 Rabbit Polyclonal Antibody
SKU:
CAB14665
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human COX15 (NP_510870.1).
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region.
Purification Method:
Affinity purification
Gene ID:
1355
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using COX15 Rabbit pAb (CAB14665) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
