The COX1 Rabbit Monoclonal Antibody (CAB4301) is a valuable tool for researchers studying Cyclooxygenase-1 (COX1), an enzyme involved in inflammatory processes and pain response. This antibody, produced using rabbit monoclonal technology, exhibits high specificity and sensitivity in detecting COX1 in human samples. Validated for use in Western blot and immunohistochemistry applications, it enables precise and accurate quantification of COX1 levels in various cell types and tissues.COX1, also known as prostaglandin-endoperoxide synthase 1, is a key enzyme in the synthesis of prostaglandins, lipid compounds involved in inflammation and pain signaling. Dysregulation of COX1 activity has been implicated in a variety of diseases, including arthritis, cancer, and cardiovascular disorders.
By studying COX1 expression and function, researchers can gain insights into the mechanisms of these diseases and potentially identify new therapeutic targets.With its reliable performance and broad utility, the COX1 Rabbit Monoclonal Antibody (CAB4301) is an essential reagent for investigations into the role of COX1 in health and disease. Whether studying basic biological processes or developing new treatment strategies, this antibody provides the precision and accuracy needed to advance scientific understanding in the fields of immunology, oncology, and pharmacology.
Product Name:
COX1/PTGS1 Rabbit Monoclonal Antibody
SKU:
CAB4301
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human COX1/PTGS1 (P23219).
This is one of two genes encoding similar enzymes that catalyze the conversion of arachidonate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5742
Clone Number:
ARC0960
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using COX1/PTGS1 Rabbit mAb (CAB4301) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
