The Corticoliberin Polyclonal Antibody (CAB1122) is a vital tool for researchers studying the role of corticoliberin, also known as corticotropin-releasing hormone (CRH), in various physiological processes. Raised in rabbits, this antibody is highly specific to human samples and is ideal for use in Western blot applications. By binding to the corticoliberin protein, this antibody allows for the detection and analysis of corticoliberin levels in different cell types.Corticoliberin is a key regulator of the hypothalamic-pituitary-adrenal (HPA) axis, playing a central role in the body's response to stress and regulating various physiological functions such as metabolism, immune response, and behavior.
Dysregulation of the HPA axis and corticoliberin signaling have been implicated in various diseases and disorders, including anxiety, depression, and certain types of cancer.By using the Corticoliberin Polyclonal Antibody (CAB1122) in their research, scientists can gain a better understanding of the mechanisms underlying corticoliberin signaling and its impact on health and disease. This antibody provides a valuable tool for studying the role of corticoliberin in various physiological and pathological processes, paving the way for the development of novel therapeutic strategies targeting the corticoliberin pathway.
Product Name:
CRH Rabbit Polyclonal Antibody
SKU:
CAB1122
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-194 of human CRH (NP_000747.1).
This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.
Purification Method:
Affinity purification
Gene ID:
1392
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CRH antibody (CAB1122) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
