The Coro7 Antibody (PAC025881) is a polyclonal antibody designed for researchers studying Coro7, a protein involved in regulating cellular processes such as vesicular trafficking and autophagy. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the Coro7 protein, researchers can detect and analyze its expression in various cell types, making it an excellent tool for investigations in cell biology and molecular biology.Coro7, also known as coronin 7, plays a crucial role in intracellular trafficking and autophagic processes, making it a key player in cellular homeostasis and maintenance.
Dysregulation of Coro7 has been implicated in various diseases such as cancer, neurodegenerative disorders, and infectious diseases. Therefore, understanding the function and regulation of Coro7 is essential for developing novel therapeutic strategies targeting these conditions.In summary, the Coro7 Antibody is a valuable research tool for scientists studying cellular processes and diseases linked to Coro7. Its specificity and sensitivity in detecting Coro7 make it an invaluable asset in advancing our understanding of this protein's role in health and disease.
F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.
coronin 7: May play a role in the maintenance of the Golgi apparatus morphology and in the protein export from the Golgi. Belongs to the WD repeat coronin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: VesicleChromosomal Location of Human Ortholog: 16p13.3Cellular Component: Golgi apparatus; integral to membrane; membrane; trans-Golgi networkMolecular Function: actin binding; protein bindingBiological Process: actin filament polymerization; Golgi to endosome transport
UniProt Protein Details:
NCBI Summary:
Coronins, such as CORO7, constitute an evolutionarily conserved family of WD-repeat actin-binding proteins. CORO7 plays a role in Golgi complex morphology and function (Rybakin et al., 2004, 2006 [PubMed 15327992] [PubMed 16905771]).[supplied by OMIM, Mar 2008]
