The COQ7 Polyclonal Antibody (CAB7768) is a valuable tool for researchers studying COQ7, a key enzyme in the biosynthesis of coenzyme Q10 (CoQ10) essential for mitochondrial function and energy production. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the COQ7 protein, researchers can accurately detect and analyze its expression levels in various cell types, providing insights into mitochondrial dysfunction and potential therapeutic strategies for related diseases.COQ7 is crucial for CoQ10 synthesis, a vital component in the electron transport chain of mitochondria that generates ATP, the energy currency of the cell. Dysregulation of CoQ10 biosynthesis can lead to mitochondrial dysfunction, resulting in various diseases such as mitochondrial myopathies, neurodegenerative disorders, and metabolic syndromes.
Research into COQ7 function and regulation is essential for developing targeted therapies to restore mitochondrial health and alleviate the symptoms of these conditions.By using the COQ7 Polyclonal Antibody (CAB7768), researchers can delve deeper into the intricacies of mitochondrial biology and energy metabolism, ultimately advancing our understanding of mitochondrial dysfunction-related diseases and uncovering potential therapeutic interventions. This antibody is a valuable asset for studies in biochemistry, mitochondrial biology, and metabolic disorders, offering precise and reliable detection of COQ7 protein levels in research applications.
Product Name:
COQ7 Rabbit Polyclonal Antibody
SKU:
CAB7768
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 37-217 of human COQ7 (NP_057222.2).
The protein encoded by this gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10229
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using COQ7 Rabbit pAb (CAB7768) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
