COQ3 Rabbit Polyclonal Antibody (CAB7469)
- SKU:
- CAB7469
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | COQ3 Rabbit Polyclonal Antibody |
SKU: | CAB7469 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-369 of human COQ3 (NP_059117.3). |
Sequence: | PGVF NEYR TIWF KSYR TIFS CLNR IKSF RYPW ARLY STSQ TTVD SGEV KTFL ALAH KWWD EQGV YAPL HSMN DLRV PFIR DNLL KTIP NHQP GKPL LGMK ILDV GCGG GLLT EPLG RLGA SVIG IDPV DENI KTAQ CHKS FDPV LDKR IEYR VCSL EEIV EETA ETFD AVVA SEVV EHVI DLET FLQC CCQV LKPG GSLF ITTI NKTQ LSYA LGIV FSEQ IASI VPKG THTW EKFV SPET LESI LESN GLSV QTVV GMLY NPFS GYWH WSEN TSLN YAAY AVKS RVQE HPAS AEFV LKGE TEEL QANA CTNP AVHE KLKK |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | DHHBMT; bA9819.1; DHHBMTASE; UG0215E05; COQ3 |
Positive Sample: | HeLa,NCI-H460,MCF7,Mouse liver,Mouse brain,Mouse heart,Mouse kidney,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Matrix side, Mitochondrion inner membrane, Peripheral membrane protein. |
Calculated MW: | 41kDa |
Observed MW: | 32kDa/41kDa |
Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.
Purification Method: | Affinity purification |
Gene ID: | 51805 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |