The COPS8 Polyclonal Antibody (CAB12745) is a vital tool for studying the function of COPS8, a protein involved in the regulation of protein degradation and cell cycle progression. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blotting and immunohistochemistry applications. By binding to COPS8, the antibody enables accurate detection and analysis of this protein in various cell types, facilitating research in fields such as cell biology and cancer biology.
COPS8, also known as COP9 signalosome complex subunit 8, is essential for the proper functioning of the COP9 signalosome complex, which regulates the activity of Cullin-RING ubiquitin ligases involved in protein degradation. Dysregulation of COPS8 has been implicated in various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions. By elucidating the role of COPS8 in cellular processes, researchers can uncover novel insights into disease mechanisms and potential treatment strategies.
Product Name:
COPS8 Rabbit Polyclonal Antibody
SKU:
CAB12745
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human COPS8 (NP_006701.1).
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Purification Method:
Affinity purification
Gene ID:
10920
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using COPS8 Rabbit pAb (CAB12745) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.