COPS7B Antibody (PACO41118)
- SKU:
- PACO41118
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | COPS7B Antibody (PACO41118) |
| Antibody SKU: | PACO41118 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human COP9 signalosome complex subunit 7b protein (1-157AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse brain tissue, Mouse stomach tissue. All lanes: COPS7B antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 30, 19, 31 kDa. Observed band size: 30 kDa. |
 | Immunofluorescent analysis of Hela cells using PACO41118 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO41118 at dilution of 1:100. |
| Background: | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
| Synonyms: | COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b), COPS7B, CSN7B |
| UniProt Protein Function: | COPS7B: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN7/EIF3M family. CSN7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 2q37.1Cellular Component: nucleoplasm; signalosomeMolecular Function: protein bindingBiological Process: cullin deneddylation; nucleotide-excision repair, DNA damage recognition; transcription-coupled nucleotide-excision repair |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9H9Q2 |
| NCBI GenInfo Identifier: | 55976598 |
| NCBI Gene ID: | 64708 |
| NCBI Accession: | Q9H9Q2.1 |
| UniProt Secondary Accession: | Q9H9Q2,Q53S22, Q5BJG3, Q9H7V6 |
| UniProt Related Accession: | Q9H9Q2 |
| Molecular Weight: | 29622 Da |
| NCBI Full Name: | COP9 signalosome complex subunit 7b |
| NCBI Synonym Full Names: | COP9 signalosome subunit 7B |
| NCBI Official Symbol: | COPS7BÂ Â |
| NCBI Official Synonym Symbols: | CSN7B; SGN7b  |
| NCBI Protein Information: | COP9 signalosome complex subunit 7b |
| UniProt Protein Name: | COP9 signalosome complex subunit 7b |
| UniProt Synonym Protein Names: | JAB1-containing signalosome subunit 7b |
| Protein Family: | COP9 signalosome complex |
| UniProt Gene Name: | COPS7BÂ Â |
| UniProt Entry Name: | CSN7B_HUMAN |