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COPS7B Antibody (PACO41118)

SKU:
PACO41118
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • COPS7B Antibody PACO41118
  • COPS7B Antibody PACO41118
  • COPS7B Antibody PACO41118
€359

Description

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COPS7B Antibody (PACO41118)

The COPS7B Polyclonal Antibody (PAC04118) is a valuable tool for researchers studying COPS7B, a subunit of the COP9 signalosome complex involved in regulating protein degradation. This antibody, produced in rabbits, shows high specificity and reactivity with human samples, making it ideal for use in Western blot applications. By targeting the COPS7B protein, this antibody enables precise detection and analysis in various cell types, facilitating research in cell biology, protein degradation pathways, and cancer biology.

COPS7B plays a crucial role in the assembly and function of the COP9 signalosome complex, which regulates the degradation of key proteins involved in cell cycle control, signal transduction, and DNA repair. Dysregulation of COPS7B has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions. Understanding the function and regulation of COPS7B is essential for unraveling its role in disease progression and identifying potential treatment strategies.

Antibody Name:COPS7B Antibody (PACO41118)
Antibody SKU:PACO41118
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human, Mouse
Immunogen:Recombinant Human COP9 signalosome complex subunit 7b protein (1-157AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: Mouse brain tissue, Mouse stomach tissue. All lanes: COPS7B antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 30, 19, 31 kDa. Observed band size: 30 kDa.
Product ImageImmunofluorescent analysis of Hela cells using PACO41118 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageImmunohistochemistry of paraffin-embedded human testis tissue using PACO41118 at dilution of 1:100.
Background:Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Synonyms:COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b), COPS7B, CSN7B
UniProt Protein Function:COPS7B: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN7/EIF3M family. CSN7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 2q37.1Cellular Component: nucleoplasm; signalosomeMolecular Function: protein bindingBiological Process: cullin deneddylation; nucleotide-excision repair, DNA damage recognition; transcription-coupled nucleotide-excision repair
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q9H9Q2
NCBI GenInfo Identifier:55976598
NCBI Gene ID:64708
NCBI Accession:Q9H9Q2.1
UniProt Secondary Accession:Q9H9Q2,Q53S22, Q5BJG3, Q9H7V6
UniProt Related Accession:Q9H9Q2
Molecular Weight:29622 Da
NCBI Full Name:COP9 signalosome complex subunit 7b
NCBI Synonym Full Names:COP9 signalosome subunit 7B
NCBI Official Symbol:COPS7B  
NCBI Official Synonym Symbols:CSN7B; SGN7b  
NCBI Protein Information:COP9 signalosome complex subunit 7b
UniProt Protein Name:COP9 signalosome complex subunit 7b
UniProt Synonym Protein Names:JAB1-containing signalosome subunit 7b
Protein Family:COP9 signalosome complex
UniProt Gene Name:COPS7B  
UniProt Entry Name:CSN7B_HUMAN
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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