The COPS6 Polyclonal Antibody (CAB7072) is a valuable tool for researchers studying COPS6, a key component of the COP9 signalosome complex involved in protein degradation and cell cycle regulation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications.COPS6, also known as COP9 signalosome subunit 6, is essential for the proper function of the COP9 signalosome complex, which regulates the stability and activity of a wide range of proteins involved in cellular processes. Dysregulation of COPS6 has been associated with various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions.
By using the COPS6 Polyclonal Antibody, researchers can accurately detect and analyze the expression levels of COPS6 in different cell types and tissues, providing valuable insights into its role in cellular processes and disease pathology. This antibody is a valuable tool for studies in molecular biology, oncology, and neurobiology, offering new possibilities for understanding and targeting COPS6-related pathways in disease.
Product Name:
COPS6 Rabbit Polyclonal Antibody
SKU:
CAB7072
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 58-327 of human COPS6 (NP_006824.2).
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.
Purification Method:
Affinity purification
Gene ID:
10980
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using COPS6 antibody (CAB7072) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
