JAB1/CSN5/COPS5 Rabbit Polyclonal Antibody (CAB13401)
- SKU:
- CAB13401
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | JAB1/CSN5/COPS5 Rabbit Polyclonal Antibody |
SKU: | CAB13401 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human JAB1/CSN5/JAB1/CSN5/COPS5 (NP_006828.2). |
Sequence: | MAAS GSGM AQKT WELA NNMQ EAQS IDEI YKYD KKQQ QEIL AAKP WTKD HHYF KYCK ISAL ALLK MVMH ARSG GNLE VMGL MLGK VDGE TMII MDSF ALPV EGTE TRVN AQAA AYEY MAAY IENA KQVG RLEN AIGW YHSH PGYG CWLS GIDV STQM LNQQ FQEP FVAV VIDP TRTI SAGK VNLG AFRT YPKG YKPP DEGP SEYQ TIPL NKIE DFGV HCKQ YYAL EVSY FKSS LDRK LLEL LWNK YWVN TLSS SSLL TNAD YTTG QVFD LSEK LEQS EAQL GRGS FMLG LETH DRKS EDKL AKAT RDSC KTTI EAIH GLMS QVIK DKLF NQIN IS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 |
Synonyms: | CSN5; JAB1; SGN5; MOV-34; JAB1/CSN5/COPS5 |
Positive Sample: | NIH/3T3,MCF7,PC-12,HeLa,K-562,DU145,Mouse brain,Mouse heart,Mouse testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasmic vesicle, Nucleus, perinuclear region, secretory vesicle, synaptic vesicle. |
Calculated MW: | 38kDa |
Observed MW: | 37kDa |
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
Purification Method: | Affinity purification |
Gene ID: | 10987 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |