The COPS3 Polyclonal Antibody (CAB7017) is specifically designed for research involving COPS3, a key protein involved in cellular processes such as protein degradation and cell cycle regulation. The antibody, raised in rabbits, is highly selective for human samples and has been validated for use in Western blot applications. By binding to the COPS3 protein, this antibody enables precise detection and analysis in various cell types, making it an essential tool for studies in molecular biology, cell biology, and cancer research.COPS3, also known as COP9 signalosome subunit 3, is a crucial component of the COP9 signalosome complex that regulates the stability of several proteins involved in cell division and growth.
Dysregulation of COPS3 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic conditions. Understanding the role of COPS3 in cellular processes is vital for developing targeted therapies that can modulate protein degradation and cell cycle progression in disease contexts.In conclusion, the COPS3 Polyclonal Antibody (CAB7017) offers researchers a powerful tool for investigating the function and regulation of COPS3 in various biological processes. Its high specificity and compatibility with Western blotting make it an invaluable asset for studies aimed at unraveling the complex mechanisms underlying cellular homeostasis and disease development.
Product Name:
COPS3 Rabbit Polyclonal Antibody
SKU:
CAB7017
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 194-423 of human COPS3 (NP_003644.2).
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8533
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using COPS3 antibody (CAB7017) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
