The COPA Polyclonal Antibody (CAB16821) is a valuable tool for researchers studying COPA, a protein involved in the regulation of vesicle trafficking and immune responses. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the COPA protein, this antibody allows for accurate detection and analysis in various cell types, making it well-suited for studies in immunology and cell biology.COPA, a key component of the coatomer protein complex, plays a crucial role in intracellular transport and the maintenance of cell structure.
Dysregulation of COPA has been linked to autoimmune diseases and inflammatory conditions, making it a promising target for therapeutic interventions. By understanding the function and regulation of COPA, researchers can gain insight into the underlying mechanisms of these diseases and potentially develop new treatment strategies. Overall, the COPA Polyclonal Antibody (CAB16821) is a reliable tool for investigating the role of COPA in cellular processes and disease pathways, offering valuable insights for future research and drug development efforts.
Product Name:
COPA Rabbit Polyclonal Antibody
SKU:
CAB16821
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 550-650 of human COPA (NP_001091868.1).
In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
1314
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver, using COPA Rabbit pAb (CAB16821) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
