CFH Rabbit Polyclonal Antibody (CAB2166)
- SKU:
- CAB2166
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | CFH Rabbit Polyclonal Antibody |
SKU: | CAB2166 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-323 of human Complement factor H (NP_000177.2). |
Sequence: | EDCN ELPP RRNT EILT GSWS DQTY PEGT QAIY KCRP GYRS LGNV IMVC RKGE WVAL NPLR KCQK RPCG HPGD TPFG TFTL TGGN VFEY GVKA VYTC NEGY QLLG EINY RECD TDGW TNDI PICE VVKC LPVT APEN GKIV SSAM EPDR EYHF GQAV RFVC NSGY KIEG DEEM HCSD DGFW SKEK PKCV EISC KSPD VING SPIS QKII YKEN ERFQ YKCN MGYE YSER GDAV CTES GWRP LPSC EEKS CDNP YIPN GDYS PLRI KHRT GDEI TYQC RNGF YPAT RGNT AKCT STGW IPAP RCTL K |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; Complement factor H |
Positive Sample: | Human plasma,Mouse liver,Mouse plasma,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 139kDa |
Observed MW: | 150kDa |
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method: | Affinity purification |
Gene ID: | 3075 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |