Complement factor D Monoclonal Antibody (CAB23006)
The Complement Factor D Monoclonal Antibody is a powerful tool for researchers investigating the role of complement factor D, a key enzyme in the alternative pathway of the complement system. This antibody, produced using hybridoma technology, specifically targets and binds to complement factor D in human samples, allowing for precise detection and analysis in a variety of research applications.Complement factor D is a crucial component of the immune response, playing a significant role in the activation and regulation of the complement system. Dysregulation of this pathway has been implicated in numerous diseases, including inflammatory disorders, autoimmune conditions, and infectious diseases.
By studying the activity of complement factor D using this monoclonal antibody, researchers can gain valuable insights into the underlying mechanisms of these conditions and potentially identify new therapeutic targets.With its high specificity and sensitivity, the Complement Factor D Monoclonal Antibody is an essential tool for researchers in the fields of immunology, infectious disease, and inflammation. Its versatility and reliability make it an ideal choice for studies aiming to unravel the complex interactions of the complement system and its role in various disease states.
Product Name:
Complement factor D Monoclonal Antibody
SKU:
CAB23006
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant protein of human Complement factor D.
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:2000 - 1:10000
Synonyms:
DF; ADN; PFD; ADIPSIN; Complement factor D
Positive Sample:
THP-1
Conjugate:
Unconjugated
Cellular Localization:
Secreted.
Calculated MW:
27kDa
Observed MW:
27kDa
This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease.
Purification Method:
Affinity purification
Gene ID:
1675
Clone Number:
ARC59438
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Complement factor D antibody (CAB23006) at 1:10000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
