Complement Factor B Rabbit Polyclonal Antibody (CAB1706)
- SKU:
- CAB1706
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | Complement Factor B Rabbit Polyclonal Antibody |
SKU: | CAB1706 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-259 of Complement factor B (CFB) (NP_001701.2). |
Sequence: | TPWS LARP QGSC SLEG VEIK GGSF RLLQ EGQA LEYV CPSG FYPY PVQT RTCR STGS WSTL KTQD QKTV RKAE CRAI HCPR PHDF ENGE YWPR SPYY NVSD EISF HCYD GYTL RGSA NRTC QVNG RWSG QTAI CDNG AGYC SNPG IPIG TRKV GSQY RLED SVTY HCSR GLTL RGSQ RRTC QEGG SWSG TEPS CQDS FMYD TPQE VAEA FLSS LTET IEGV DAED GHGP GEQQ KR |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | BF; FB; BFD; GBG; CFAB; CFBD; PBF2; AHUS4; FBI12; H2-Bf; ARMD14; Complement factor B (CFB) |
Positive Sample: | Human plasma,Mousep plasma,Rat plasma |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 86kDa |
Observed MW: | 100kDa |
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
Purification Method: | Affinity purification |
Gene ID: | 629 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |