Complement Factor B Rabbit Polyclonal Antibody (CAB1706)
The Complement Factor B Polyclonal Antibody (CAB1706) is specifically designed for research involving Complement Factor B, a key protein in the complement system that plays a crucial role in immune response and inflammation. The antibody is raised in rabbits and is highly reactive with human samples, making it an ideal tool for studies in immunology and inflammation-related research.Complement Factor B is a critical component of the alternative pathway of the complement system, which is important for enhancing immune responses and fighting against infections. Dysregulation of Complement Factor B has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and kidney diseases.
Therefore, understanding the regulation and function of Complement Factor B is essential for developing targeted therapies and diagnostic tools for these diseases.The CAB1706 antibody binds specifically to Complement Factor B protein, enabling researchers to detect and analyze its expression levels in various cell types and tissues. It is validated for use in Western blot applications, providing accurate and reliable results for your experiments. By using the CAB1706 antibody, researchers can further elucidate the role of Complement Factor B in immune response and inflammation, paving the way for the development of novel therapeutic strategies.
Product Name:
Complement Factor B Rabbit Polyclonal Antibody
SKU:
CAB1706
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-259 of Complement factor B (CFB) (NP_001701.2).
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
Purification Method:
Affinity purification
Gene ID:
629
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Complement factor B (CFB) Rabbit pAb (CAB1706) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
