The Complement C5 Polyclonal Antibody (CAB8104) from AssayGenie is a valuable tool for researchers investigating the role of Complement C5 in immune response and inflammatory processes. Complement C5 is a protein involved in the complement system, a crucial component of the body's immune defense mechanism.Raised in rabbits, this antibody is highly specific for human samples and has been validated for use in Western blot applications. By targeting Complement C5, researchers can detect and analyze the protein in various cell types, providing valuable insights into its function in immunology and disease pathology.Complement C5 is known to play a key role in the activation of the complement cascade, leading to the elimination of pathogens and damaged cells.
Dysregulation of this pathway has been implicated in various inflammatory conditions, making Complement C5 a potential therapeutic target for diseases such as autoimmune disorders and chronic inflammatory conditions.By using the Complement C5 Polyclonal Antibody, researchers can deepen their understanding of the role of Complement C5 in immune regulation and inflammation, paving the way for the development of novel therapies targeting this critical pathway. Order your CAB8104 antibody from AssayGenie today to advance your research in immunology and disease biology.
Product Name:
C5/C5a Rabbit Polyclonal Antibody
SKU:
CAB8104
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1567-1676 of human C5/C5a (NP_001726.2).
This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
727
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung, using C5/C5a Rabbit pAb (CAB8104) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
