Complement C3 Polyclonal Antibody (CAB6879)
- SKU:
- CAB6879
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | Complement C3 Polyclonal Antibody |
SKU: | CAB6879 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1364-1663 of human Complement C3 (NP_000055.2). |
Sequence: | KVTI KPAP ETEK RPQD AKNT MILE ICTR YRGD QDAT MSIL DISM MTGF APDT DDLK QLAN GVDR YISK YELD KAFS DRNT LIIY LDKV SHSE DDCL AFKV HQYF NVEL IQPG AVKV YAYY NLEE SCTR FYHP EKED GKLN KLCR DELC RCAE ENCF IQKS DDKV TLEE RLDK ACEP GVDY VYKT RLVK VQLS NDFD EYIM AIEQ TIKS GSDE VQVG QQRT FISP IKCR EALK LEEK KHYL MWGL SSDF WGEK PNLS YIIG KDTW VEHW PEED ECQD EENQ KQCQ DLGA FTES MVVF GCPN |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:100 |
Synonyms: | ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p; Complement C3 |
Positive Sample: | HepG2,Mouse plasma,Rat plasma |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 187kDa |
Observed MW: | 187kDa/115kDa |
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.
Purification Method: | Affinity purification |
Gene ID: | 718 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |