The Complement C3A Polyclonal Antibody (CAB6879) is a powerful tool for researchers studying the complement system, a key component of the immune response. This antibody, produced in rabbits, specifically targets Complement C3A, a central protein in the complement cascade that plays a crucial role in inflammation and host defense.Validated for use in Western blot applications, the Complement C3A Polyclonal Antibody enables precise detection and analysis of Complement C3A protein levels in a variety of samples. Its high reactivity with human samples makes it an ideal choice for studies in immunology, inflammatory diseases, and complement-related disorders.
Complement C3A is known for its ability to trigger inflammation and enhance immune responses against pathogens. Dysregulation of the complement system, including Complement C3A, has been implicated in various diseases, such as autoimmune disorders, infectious diseases, and cardiovascular conditions. By investigating the role of Complement C3A with this antibody, researchers can gain valuable insights into disease mechanisms and potential therapeutic targets within the complement cascade.
Product Name:
Complement C3 Polyclonal Antibody
SKU:
CAB6879
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1364-1663 of human Complement C3 (NP_000055.2).
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.
Purification Method:
Affinity purification
Gene ID:
718
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Complement C3 Rabbit pAb (CAB6879) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
