The Complement C3 Monoclonal Antibody is a valuable tool for researchers studying the complement system, a key component of the immune system. This antibody, produced using recombinant technology, specifically targets the Complement C3 protein, which plays a crucial role in the complement cascade and immune response.The antibody is highly specific to human samples and is suitable for use in various applications, including Western blotting and immunohistochemistry. Its high binding affinity allows for precise detection and analysis of Complement C3 in different cell types and tissues.Complement C3 is essential for both innate and adaptive immune responses, with dysregulation of its activity implicated in various diseases, including autoimmune disorders and inflammatory conditions.
By studying the role of Complement C3 in these diseases, researchers can gain valuable insights into potential therapeutic targets and treatment strategies.Overall, the Complement C3 Monoclonal Antibody is a valuable tool for investigating the complex mechanisms of the complement system and its implications in immune-related diseases, paving the way for future advancements in immunology and drug development.
Product Name:
Complement C3 Monoclonal Antibody
SKU:
CAB22265
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1364-1663 of mouse Complement C3 (NP_033908.2).
This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the complement system. The encoded preproprotein undergoes a multi-step processing to generate various functional peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon infection, display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy, and develop severe lung injury after deposition of IgG immune complexes. Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections, age-related macular degeneration, and atypical hemolytic uremic syndrome.
Purification Method:
Affinity purification
Gene ID:
12266
Clone Number:
ARC56851
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of Mouse liver, using Complement C3 antibody (CAB22265) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
