Complement C3 Monoclonal Antibody (CAB22265)
- SKU:
- CAB22265
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Frequently bought together:
Description
Product Name: | Complement C3 Monoclonal Antibody |
SKU: | CAB22265 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1364-1663 of mouse Complement C3 (NP_033908.2). |
Sequence: | RVSI RPAP ETAK KPEE AKNT MFLE ICTK YLGD VDAT MSIL DISM MTGF APDT KDLE LLAS GVDR YISK YEMN KAFS NKNT LIIY LEKI SHTE EDCL TFKV HQYF NVGL IQPG SVKV YSYY NLEE SCTR FYHP EKDD GMLS KLCH SEMC RCAE ENCF MQQS QEKI NLNV RLDK ACEP GVDY VYKT ELTN IELL DDFD EYTM TIQQ VIKS GSDE VQAG QQRK FISH IKCR NALK LQKG KKYL MWGL SSDL WGEK PNTS YIIG KDTW VEHW PEAE ECQD QKYQ KQCE ELGA FTES MVVY GCPN |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | ASP; Plp; HSE-MSF; Complement C3 |
Positive Sample: | Mouse liver,Rat liver,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell surface, Extracellular region, Extracellular space, Plasma membrane |
Calculated MW: | 186kDa |
Observed MW: | 115kDa/187kDa |
This gene encodes complement protein C3 which plays a central role in the classical, alternative and lectin activation pathways of the complement system. The encoded preproprotein undergoes a multi-step processing to generate various functional peptides. Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon infection, display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy, and develop severe lung injury after deposition of IgG immune complexes. Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections, age-related macular degeneration, and atypical hemolytic uremic syndrome.
Purification Method: | Affinity purification |
Gene ID: | 12266 |
Clone Number: | ARC56851 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |