The Complement C2 Polyclonal Antibody (CAB10186) is a valuable tool for researchers studying the complement system and its role in immune responses. This antibody, raised in rabbits, specifically targets the Complement C2 protein, a key component of the complement cascade involved in promoting inflammation and opsonization of pathogens.Validated for use in Western blot applications, this antibody is highly reactive with human samples, allowing for the detection and analysis of Complement C2 in various cell types. Its utility in immunology research makes it ideal for studies focusing on the role of the complement system in diseases such as autoimmune disorders, infectious diseases, and inflammatory conditions.
By targeting Complement C2, researchers can gain insights into the immune response and identify potential therapeutic strategies for manipulating the complement cascade in disease settings. The Complement C2 Polyclonal Antibody is a valuable tool for advancing our understanding of immune regulation and inflammation, with implications for the development of new treatments for a range of immune-related conditions.
Product Name:
C2 Rabbit Polyclonal Antibody
SKU:
CAB10186
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 453-752 of human C2 (NP_000054.2).
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
Purification Method:
Affinity purification
Gene ID:
717
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using C2 Antibody (CAB10186) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
