C2 Rabbit Polyclonal Antibody (CAB10186)
- SKU:
- CAB10186
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | C2 Rabbit Polyclonal Antibody |
SKU: | CAB10186 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 453-752 of human C2 (NP_000054.2). |
Sequence: | LDVS KLTD TICG VGNM SANA SDQE RTPW HVTI KPKS QETC RGAL ISDQ WVLT AAHC FRDG NDHS LWRV NVGD PKSQ WGKE FLIE KAVI SPGF DVFA KKNQ GILE FYGD DIAL LKLA QKVK MSTH ARPI CLPC TMEA NLAL RRPQ GSTC RDHE NELL NKQS VPAH FVAL NGSK LNIN LKMG VEWT SCAE VVSQ EKTM FPNL TDVR EVVT DQFL CSGT QEDE SPCK GESG GAVF LERR FRFF QVGL VSWG LYNP CLGS ADKN SRKR APRS KVPP PRDF HINL FRMQ PWLR QHLG DVLN FLPL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CO2; ARMD14; C2 |
Positive Sample: | LO2,293T,U-87MG |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 83kDa |
Observed MW: | 70kDa/110kDa |
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 717 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |