The COMP Polyclonal Antibody (CAB13963) is a versatile tool for researchers studying the role of cartilage oligomeric matrix protein (COMP) in various biological processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting COMP in human samples, making it an invaluable resource for experiments requiring reliable detection of this protein.COMP is a key component of the extracellular matrix in cartilage and other connective tissues, playing important roles in maintaining tissue integrity and promoting cell adhesion.
Dysregulation of COMP has been linked to various musculoskeletal disorders, making it a promising target for therapeutic interventions.The COMP Polyclonal Antibody is validated for use in techniques such as Western blotting and immunohistochemistry, allowing researchers to explore the expression, localization, and function of COMP in different cell types and tissues. By using this antibody, scientists can delve deeper into the mechanisms underlying COMP-related diseases and potentially uncover new therapeutic avenues for treating these conditions.
Product Name:
COMP Rabbit Polyclonal Antibody
SKU:
CAB13963
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human COMP (NP_000086.2).
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
Purification Method:
Affinity purification
Gene ID:
1311
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using COMP antibody (CAB13963) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
