The COMM domain containing protein 2 (COMMD2) Polyclonal Antibody (PACO37474) is a valuable tool for researchers studying the function of the COMMD2 protein in cell biology and disease. This antibody, generated in rabbits, has been validated for use in various applications, including Western blot and immunofluorescence.COMMD2, a member of the COMMD protein family, has been implicated in various cellular processes, such as copper homeostasis, NF-κB signaling, and protein trafficking. Dysregulation of COMMD2 has been associated with diseases like cancer, neurodegenerative disorders, and inflammatory conditions, making it an important target for research.
By using the COMMD2 Polyclonal Antibody, researchers can detect and analyze the expression of COMMD2 in different cell types and tissues, providing insights into its role in cellular functions and disease pathology. This antibody is essential for studies aimed at understanding the molecular mechanisms involving COMMD2 and exploring its therapeutic potential in various diseases.
Antibody Name:
COMMD2 Antibody (PACO37474)
Antibody SKU:
PACO37474
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human COMM domain-containing protein 2 protein (5-199AA)
Immunohistochemistry of paraffin-embedded human colon cancer using PACO37474 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO37474 at dilution of 1:100.
Background:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B.
Synonyms:
COMM domain-containing protein 2, COMMD2
UniProt Protein Function:
COMMD2: May down-regulate activation of NF-kappa-B.Chromosomal Location of Human Ortholog: 3q25.1Cellular Component: cytoplasmMolecular Function: protein bindingBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
