The COMMD1 Polyclonal Antibody (CAB7149) is a valuable tool for researchers studying COMMD1, a protein involved in various cellular processes, including regulation of copper homeostasis and NF-κB signaling. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.COMMD1, also known as copper metabolism MURR1 domain-containing protein 1, plays a crucial role in maintaining cellular copper levels and modulating NF-κB signaling, which is involved in inflammation and immune response. Dysregulation of COMMD1 has been linked to conditions such as Wilson's disease and cancer, making it a promising target for therapeutic interventions.
By using the COMMD1 Polyclonal Antibody, researchers can detect and analyze the expression of COMMD1 in various cell types, providing valuable insights into its function and potential implications in disease pathology. This antibody is particularly useful for studies in the fields of molecular biology, metabolism, and cancer research, offering a versatile tool for investigating the role of COMMD1 in health and disease.
Product Name:
COMMD1 Rabbit Polyclonal Antibody
SKU:
CAB7149
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human COMMD1 (NP_689729.1).
Cytoplasm, Cytoplasmic vesicle, Early endosome, Endosome membrane, Nucleus, Recycling endosome.
Calculated MW:
21kDa
Observed MW:
Refer to figures
Enables several functions, including phosphatidylinositol-3,4-bisphosphate binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including Golgi to plasma membrane transport; negative regulation of protein localization to cell surface; and regulation of cellular protein metabolic process. Acts upstream of or within negative regulation of NF-kappaB transcription factor activity. Located in cytosol; endosome; and nucleoplasm. Part of Cul2-RING ubiquitin ligase complex.
Purification Method:
Affinity purification
Gene ID:
150684
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of L929 cells using COMMD1 antibody (CAB7149) at dilution of 1:100. Blue: DAPI for nuclear staining.
