The Collagenase-3 Polyclonal Antibody (CAB1606) is a vital tool for researchers studying collagenase-3, a key enzyme involved in extracellular matrix degradation and tissue remodeling. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications. By targeting collagenase-3, this antibody enables precise detection and analysis of this enzyme in various cell types, facilitating investigations in fields such as tissue engineering, wound healing, and cancer metastasis.Collagenase-3, also known as matrix metalloproteinase-13 (MMP-13), plays a crucial role in tissue repair and pathological processes by breaking down collagen in the extracellular matrix.
Its dysregulation has been implicated in various diseases, including arthritis, cardiovascular conditions, and cancer progression. Therefore, understanding the expression and activity of collagenase-3 is essential for developing targeted therapies and diagnostic tools for these disorders. The Collagenase-3 Polyclonal Antibody (CAB1606) provides researchers with a reliable tool to delve deeper into the functions of this enzyme and its potential implications in disease mechanisms.
Product Name:
MMP13 Rabbit Polyclonal Antibody
SKU:
CAB1606
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 262-471 of human MMP13 (NP_002418.1).
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11.
Purification Method:
Affinity purification
Gene ID:
4322
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MMP13 antibody (CAB1606) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
