Collagen XVII/COL17A1 Rabbit Monoclonal Antibody (CAB4808)
- SKU:
- CAB4808
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | Collagen XVII/COL17A1 Rabbit Monoclonal Antibody |
SKU: | CAB4808 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1300-1400 of human Collagen XVII/COL17A1 (Q9UMD9). |
Sequence: | SVRR GSSY SSSM STGG GGAG SLGA GGAF GEAA GDRG PYGT DIGP GGGY GAAA EGGM YAGN GGLL GADF AGDL DYNE LAVR VSES MQRQ GLLQ GMAY TVQG P |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | ERED; JEB4; BP180; BPA-2; BPAG2; LAD-1; BA16H23.2; Collagen XVII/COL17A1 |
Positive Sample: | A431 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Membrane, Secreted, Single-pass type II membrane protein, basement membrane, extracellular matrix, extracellular space, hemidesmosome. |
Calculated MW: | 150kDa |
Observed MW: | 150-180kDa |
This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.
Purification Method: | Affinity purification |
Gene ID: | 1308 |
Clone Number: | ARC0233 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |