The Collagen II Polyclonal Antibody is a vital tool for researchers studying collagen II, a key component of cartilage and other connective tissues in the body. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to collagen II, this antibody allows for precise detection and analysis of this important protein in a variety of cell types.Collagen II is essential for maintaining the structural integrity and function of cartilage, making it a critical focus in studies related to musculoskeletal health, joint diseases, and tissue repair.
This antibody enables researchers to explore the role of collagen II in these areas, providing valuable insights into mechanisms of cartilage degradation, osteoarthritis, and potential therapeutic interventions.With its ability to target collagen II with precision and sensitivity, the Collagen II Polyclonal Antibody is an indispensable tool for investigations in orthopedics, rheumatology, and regenerative medicine. Its potential applications extend to preclinical drug development, biomarker discovery, and understanding the underlying pathophysiology of collagen-related disorders.
Product Name:
Collagen II Polyclonal Antibody
SKU:
CAB24334
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human Collagen II. (NP_001835.3).
This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.
Purification Method:
Affinity purification
Gene ID:
1280
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Collagen II Rabbit pAb (CAB24334) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
