The COL9A1 Polyclonal Antibody (CAB6563) is a powerful tool for researchers studying COL9A1, a protein involved in the formation of collagen fibrils in cartilage tissues. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the COL9A1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an invaluable asset for investigations in musculoskeletal biology and orthopedic research.COL9A1 is a crucial component of type IX collagen, which plays a key role in maintaining the structural integrity and mechanical properties of cartilage.
Mutations in the COL9A1 gene have been linked to various skeletal disorders, including osteoarthritis and intervertebral disc diseases. Understanding the functions and interactions of COL9A1 is essential for advancing our knowledge of cartilage biology and developing targeted therapies for these debilitating conditions. The COL9A1 Polyclonal Antibody provides researchers with a reliable tool to study the role of COL9A1 in health and disease, ultimately paving the way for new treatments and interventions in the field of musculoskeletal research.
Product Name:
COL9A1 Rabbit Polyclonal Antibody
SKU:
CAB6563
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human COL9A1 (NP_001842.3).
This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in this gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, and with Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects. Two transcript variants that encode different isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
1297
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using COL9A1 Rabbit pAb antibody (CAB6563) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
