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COL8A2 Antibody (PACO20975)

SKU:
PACO20975
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • COL8A2 Antibody PACO20975
  • COL8A2 Antibody PACO20975
$407

Description

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COL8A2 Antibody (PACO20975)

The COL8A2 Polyclonal Antibody (PAC020975) is a valuable tool for researchers studying COL8A2, a collagen protein involved in extracellular matrix formation and tissue structure. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is suitable for use in Western blot applications. By targeting the COL8A2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for investigations in the fields of cell biology and tissue engineering.COL8A2, a member of the collagen superfamily, plays a crucial role in maintaining the structural integrity of tissues such as the cornea and cartilage.

Dysregulation of COL8A2 has been associated with various pathological conditions, including corneal dystrophies and osteoarthritis. Therefore, understanding the function and regulation of COL8A2 is essential for developing targeted therapies and interventions for these disorders.By utilizing the COL8A2 Polyclonal Antibody (PAC020975), researchers can expand their knowledge of COL8A2 biology and potentially contribute to the development of novel treatment strategies for conditions characterized by aberrant collagen synthesis and tissue remodeling.

Antibody Name:COL8A2 Antibody (PACO20975)
Antibody SKU:PACO20975
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:Human, Mouse
Immunogen:Synthetic peptide of human COL8A2
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20975(COL8A2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20975(COL8A2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:This gene encodes the α 2 chain of type VIII collagen. This protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with α 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2. Alternative splicing results in multiple transcript variants.
Synonyms:collagen, type VIII, α 2
UniProt Protein Function:COL8A2: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. Defects in COL8A2 are the cause of corneal dystrophy Fuchs endothelial type 1 (FECD1). It is an ocular disorder caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition. Defects in COL8A2 are the cause of posterior polymorphous corneal dystrophy type 2 (PPCD2). PPCD is a rare bilateral familial disorder of the corneal epithelium, and is inherited in a autosomal dominant pattern. The clinical features usually present earlier than FECD, being from birth onwards. The disorder is characterized by alterations of Descemet membrane presenting as vesicles, opacities or band-like lesions on slit- lamp examination and specular microscopy. Affected patient typically are asymptomatic.Protein type: Secreted, signal peptide; Secreted; Extracellular matrixChromosomal Location of Human Ortholog: 1p34.2Cellular Component: endoplasmic reticulum lumen; extracellular matrix; extracellular regionBiological Process: collagen catabolic process; extracellular matrix organization and biogenesisDisease: Corneal Dystrophy, Fuchs Endothelial, 1; Corneal Dystrophy, Posterior Polymorphous, 2
UniProt Protein Details:
NCBI Summary:This gene encodes the alpha 2 chain of type VIII collagen. This protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
UniProt Code:P25067
NCBI GenInfo Identifier:45644957
NCBI Gene ID:1296
NCBI Accession:P25067.2
UniProt Secondary Accession:P25067,Q5JV31, Q8TEJ5
UniProt Related Accession:P25067
Molecular Weight:67,244 Da
NCBI Full Name:Collagen alpha-2(VIII) chain
NCBI Synonym Full Names:collagen type VIII alpha 2 chain
NCBI Official Symbol:COL8A2  
NCBI Official Synonym Symbols:FECD; PPCD; FECD1; PPCD2  
NCBI Protein Information:collagen alpha-2(VIII) chain
UniProt Protein Name:Collagen alpha-2(VIII) chain
UniProt Synonym Protein Names:Endothelial collagen
Protein Family:
UniProt Gene Name:COL8A2  
UniProt Entry Name:CO8A2_HUMAN
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