The COL6A6 Polyclonal Antibody (PAC035022) is a valuable tool for researchers studying the COL6A6 protein, a component of the collagen VI family known for its role in extracellular matrix organization. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in various applications, including Western blot analysis. By specifically binding to COL6A6, this antibody enables researchers to detect and study the protein in different cell types, making it an ideal choice for investigations in the fields of biology and medicine.
COL6A6 is a crucial player in maintaining tissue structure and function, particularly in the context of connective tissues like skin and cartilage. Dysregulation of COL6A6 expression or function has been implicated in various diseases, including muscular dystrophy and certain skin disorders. By gaining insights into the mechanisms underlying COL6A6's activity, researchers can potentially uncover new therapeutic targets for treating these conditions and improving patient outcomes.
Antibody Name:
COL6A6 Antibody (PACO35022)
Antibody SKU:
PACO35022
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Collagen alpha-6(VI) chain protein (430-982AA)
Immunohistochemistry of paraffin-embedded human liver tissue using PACO35022 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO35022 at dilution of 1:100.
Background:
Collagen VI acts as a cell-binding protein.
Synonyms:
Collagen alpha-6(VI) chain, COL6A6
UniProt Protein Function:
COL6A6: Collagen VI acts as a cell-binding protein. Belongs to the type VI collagen family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 3q22.1Cellular Component: extracellular region; proteinaceous extracellular matrixBiological Process: collagen catabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a large protein that contains multiple von Willebrand factor domains and forms a component of the basal lamina of epithelial cells. This protein may regulate epithelial cell-fibronectin interactions. Variation in this gene may be implicated in skin diseases. [provided by RefSeq, May 2017]
