The COL6A2 Polyclonal Antibody (CAB3796) is a valuable tool for researchers studying collagen type VI alpha 2 (COL6A2), a key component of the extracellular matrix. This antibody is raised in rabbits and has been validated for use in Western blot applications, making it ideal for investigating the expression and function of COL6A2 in various cell types.COL6A2 is known to play a critical role in maintaining tissue structure and integrity, particularly in connective tissues such as skin, cartilage, and blood vessels. Dysregulation of COL6A2 has been linked to a variety of diseases, including muscular dystrophies, myopathies, and connective tissue disorders.
By using the COL6A2 Polyclonal Antibody, researchers can explore the role of COL6A2 in these conditions and gain insights into potential therapeutic targets.Overall, the COL6A2 Polyclonal Antibody is a valuable tool for researchers interested in studying the function of COL6A2 in health and disease. Its high reactivity with human samples and specificity for COL6A2 make it a reliable option for investigations in the fields of molecular biology, biochemistry, and pathology.
Product Name:
COL6A2 Rabbit Polyclonal Antibody
SKU:
CAB3796
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 720-1019 of human COL6A2 (NP_001840.3).
This gene encodes one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The product of this gene contains several domains similar to von Willebrand Factor type A domains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in this gene are associated with Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. Three transcript variants have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
1292
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using COL6A2 antibody (CAB3796) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 40s.
