The Col4A2 Polyclonal Antibody (CAB7657) is a valuable tool for researchers studying Col4A2, a type IV collagen protein that plays a crucial role in the structure and function of basement membranes. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in immunohistochemistry and immunofluorescence applications.Col4A2 is involved in maintaining the integrity and stability of basement membranes in various tissues, including the blood vessels, kidneys, and skin. Dysregulation of Col4A2 has been implicated in a variety of diseases, such as Alport syndrome, diabetic nephropathy, and certain types of cancer. Understanding the expression and localization of Col4A2 is essential for elucidating its role in these pathologies and exploring its potential as a therapeutic target.
The Col4A2 Polyclonal Antibody enables precise detection and visualization of Col4A2 protein in tissue samples, facilitating in-depth analysis of its distribution and abundance. By studying the expression patterns of Col4A2, researchers can gain insights into its involvement in basement membrane function and its implications for disease pathology. This antibody is a valuable resource for investigations in areas such as tissue remodeling, fibrosis, and vascular biology, advancing our understanding of the role of Col4A2 in health and disease.
Product Name:
COL4A2 Rabbit Polyclonal Antibody
SKU:
CAB7657
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1486-1712 of human COL4A2 (NP_001837.2).
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
Purification Method:
Affinity purification
Gene ID:
1284
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of HeLa, using COL4A2 Rabbit pAb (CAB7657) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
