The COL25A1 Polyclonal Antibody (PACO08510) is a valuable tool for researchers studying COL25A1, a collagen protein that plays a key role in the extracellular matrix of various tissues. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the COL25A1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in tissue development, wound healing, and fibrosis research.COL25A1 is a critical component of the extracellular matrix, contributing to the structural integrity and function of tissues such as skin, cartilage, and blood vessels. Dysregulation of COL25A1 has been implicated in numerous diseases and conditions, including fibrotic disorders, connective tissue disorders, and cancer metastasis.
Understanding the role of COL25A1 in these processes is essential for developing targeted therapies and interventions aimed at restoring tissue balance and function.Researchers in fields such as molecular biology, tissue engineering, and regenerative medicine will find the COL25A1 Polyclonal Antibody (PACO08510) to be a valuable asset in their research endeavors. Its high specificity and sensitivity make it a reliable tool for studying the expression and function of COL25A1 in various biological contexts, ultimately advancing our understanding of tissue development and disease pathology.
COL25A1: Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 4q25Cellular Component: extracellular space; collagen; endoplasmic reticulum lumen; integral to plasma membrane; integral to membrane; plasma membrane; extracellular regionMolecular Function: heparin binding; beta-amyloid bindingBiological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesisDisease: Fibrosis Of Extraocular Muscles, Congenital, 5
UniProt Protein Details:
NCBI Summary:
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
