UniProt Protein Function: | COL25A1: Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 4q25Cellular Component: extracellular space; collagen; endoplasmic reticulum lumen; integral to plasma membrane; integral to membrane; plasma membrane; extracellular regionMolecular Function: heparin binding; beta-amyloid bindingBiological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesisDisease: Fibrosis Of Extraocular Muscles, Congenital, 5 |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q9BXS0 |
NCBI GenInfo Identifier: | 38570075 |
NCBI Gene ID: | 84570 |
NCBI Accession: | NP_942014.1 |
UniProt Secondary Accession: | Q9BXS0,Q9BXR9, A8MPZ6 |
UniProt Related Accession: | Q9BXS0 |
Molecular Weight: | 64,771 Da |
NCBI Full Name: | collagen alpha-1(XXV) chain isoform 1 |
NCBI Synonym Full Names: | collagen, type XXV, alpha 1 |
NCBI Official Symbol: | COL25A1Â Â |
NCBI Official Synonym Symbols: | AMY; CLAC; CLACP; CLAC-PÂ Â |
NCBI Protein Information: | collagen alpha-1(XXV) chain; collagen alpha-1(XXV) chain; alzheimer disease amyloid-associated protein; collagenous Alzheimer amyloid plaque component; collagen-like Alzheimer amyloid plaque component |
UniProt Protein Name: | Collagen alpha-1(XXV) chain |
UniProt Synonym Protein Names: | Alzheimer disease amyloid-associated protein; AMY; CLAC-P |
Protein Family: | Ribonuclease clavin |
UniProt Gene Name: | COL25A1Â Â |
UniProt Entry Name: | COPA1_HUMAN |