The COL1A2 Polyclonal Antibody (CAB5786) is a vital tool for researchers studying collagen type I alpha 2, a key component of the extracellular matrix in connective tissues. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting COL1A2 in human samples, making it an essential tool for applications such as Western blot analysis. By binding to the COL1A2 protein, this antibody facilitates precise detection and analysis in various cell types, offering researchers valuable insights into the role of collagen type I alpha 2 in normal physiology and disease states.Collagen type I alpha 2 is essential for the structural integrity and function of various tissues in the body, including bone, skin, and tendons.
Dysregulation of COL1A2 expression or function is associated with a range of disorders, such as osteogenesis imperfecta and certain types of Ehlers-Danlos syndrome. By investigating the role of COL1A2 using this antibody, researchers can uncover new therapeutic targets and strategies for treating conditions related to collagen dysfunction.Overall, the COL1A2 Polyclonal Antibody (CAB5786) is a valuable tool for researchers interested in understanding the biology of collagen type I alpha 2 and its impact on human health. Its high specificity, sensitivity, and reliability make it an indispensable asset for studies in fields such as connective tissue biology, musculoskeletal disorders, and regenerative medicine.
Product Name:
COL1A2 Rabbit Polyclonal Antibody
SKU:
CAB5786
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 501-600 of human Collagen I/COL1A2 (NP_000080.2).
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
1278
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Collagen I/COL1A2 Rabbit pAb (CAB5786) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Negative control (NC):JurkatExposure time: 30s.
