The COL1A1 Polyclonal Antibody (CAB16891) is a valuable tool for researchers studying collagen type I alpha 1 (COL1A1), a key component of the extracellular matrix and essential for maintaining tissue structure and strength. This antibody, generated in rabbits, specifically recognizes COL1A1 in human samples and has been validated for use in Western blotting applications.COL1A1 is involved in a variety of biological processes, including wound healing, fibrosis, and bone formation. Dysregulation of COL1A1 expression is associated with numerous diseases, such as fibrotic disorders, osteogenesis imperfecta, and certain types of cancer.
The ability to accurately detect and measure COL1A1 levels in different cell types allows researchers to investigate its role in these pathological conditions and explore potential therapeutic strategies targeting this protein.With its high reactivity and specificity for COL1A1, the CAB16891 antibody is a valuable tool for elucidating the functions of this important protein in various physiological and pathological contexts. Its use in research may lead to new insights into the pathogenesis of collagen-related diseases and the development of novel treatment approaches targeting COL1A1.
Product Name:
COL1A1 Rabbit Polyclonal Antibody
SKU:
CAB16891
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1120-1218 of human Collagen I/COL1A1 (NP_000079.2).
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
1277
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Collagen I/COL1A1 Rabbit pAb (CAB16891) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
