COL1A1 Rabbit Polyclonal Antibody (CAB16891)
- SKU:
- CAB16891
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | COL1A1 Rabbit Polyclonal Antibody |
SKU: | CAB16891 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1120-1218 of human Collagen I/COL1A1 (NP_000079.2). |
Sequence: | HRGF SGLQ GPPG PPGS PGEQ GPSG ASGP AGPR GPPG SAGA PGKD GLNG LPGP IGPP GPRG RTGD AGPV GPPG PPGP PGPP GPPS AGFD FSFL PQPP QEKA HDGG RYYR A |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IHC-P,1:2000 - 1:10000 IF/ICC,1:50 - 1:200 |
Synonyms: | OI1; OI2; OI3; OI4; EDSC; CAFYD; EDSARTH1; Collagen I/COL1A1 |
Positive Sample: | U-118MG,HT-29(negative) |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 139kDa |
Observed MW: | 140kDa/220kDa |
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Purification Method: | Affinity purification |
Gene ID: | 1277 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |