Col1a1 Antibody (PACO25857)
- SKU:
- PACO25857
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Col1a1 Antibody (PACO25857)
The COL1A1 Polyclonal Antibody (PACO25857) is a valuable tool for researchers studying the COL1A1 gene, which encodes the alpha-1 chain of type I collagen. Type I collagen is the most abundant protein in the extracellular matrix and plays a crucial role in the structure and strength of connective tissues such as bone, skin, and tendons. This antibody, raised in rabbits, is highly specific to human COL1A1 and has been validated for use in Western blot and immunohistochemistry applications. It binds specifically to the COL1A1 protein, allowing for accurate detection and analysis in various cell types and tissues.
The COL1A1 gene is implicated in a variety of diseases and conditions, including osteogenesis imperfecta, Ehlers-Danlos syndrome, and fibrosis. By studying the expression and regulation of COL1A1, researchers can gain insights into the pathogenesis of these disorders and potentially identify new therapeutic targets.Overall, the COL1A1 Polyclonal Antibody (PACO25857) is a valuable tool for researchers interested in exploring the role of type I collagen in health and disease, and it promises to contribute to advancements in the fields of connective tissue biology and regenerative medicine.
| Antibody Name: | Col1a1 Antibody (PACO25857) |
| Antibody SKU: | PACO25857 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:10-1:100 |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat Collagen alpha-1(I) chain protein (955-1207AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO25857 at dilution of 1:20. |
| Synonyms: | Collagen alpha-1(I) chain (Alpha-1 type I collagen), Col1a1 |
| UniProt Protein Function: | COL1A1: Type I collagen is a member of group I collagen (fibrillar forming collagen). Defects in COL1A1 are the cause of Caffey disease (CAFFD); also known as infantile cortical hyperostosis. Caffey disease is characterized by an infantile episode of massive subperiosteal new bone formation that typically involves the diaphyses of the long bones, mandible, and clavicles. The involved bones may also appear inflamed, with painful swelling and systemic fever often accompanying the illness. The bone changes usually begin before 5 months of age and resolve before 2 years of age. Defects in COL1A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL1A1 are the cause of Ehlers-Danlos syndrome type 7A (EDS7A); also known as autosomal dominant Ehlers-Danlos syndrome type VII. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7A is marked by bilateral congenital hip dislocation, hyperlaxity of the joints, and recurrent partial dislocations. Defects in COL1A1 are a cause of osteogenesis imperfecta type 1 (OI1). A dominantly inherited connective tissue disorder characterized by bone fragility and blue sclerae. Osteogenesis imperfecta type 1 is non-deforming with normal height or mild short stature, and no dentinogenesis imperfecta. Defects in COL1A1 are a cause of osteogenesis imperfecta type 2 (OI2); also known as osteogenesis imperfecta congenita. A connective tissue disorder characterized by bone fragility, with many perinatal fractures, severe bowing of long bones, undermineralization, and death in the perinatal period due to respiratory insufficiency. Defects in COL1A1 are a cause of osteogenesis imperfecta type 3 (OI3). A connective tissue disorder characterized by progressively deforming bones, very short stature, a triangular face, severe scoliosis, grayish sclera, and dentinogenesis imperfecta. Defects in COL1A1 are a cause of osteogenesis imperfecta type 4 (OI4); also known as osteogenesis imperfecta with normal sclerae. A connective tissue disorder characterized by moderately short stature, mild to moderate scoliosis, grayish or white sclera and dentinogenesis imperfecta. Genetic variations in COL1A1 are a cause of susceptibility to osteoporosis (OSTEOP); also known as involutional or senile osteoporosis or postmenopausal osteoporosis. Osteoporosis is characterized by reduced bone mass, disruption of bone microarchitecture without alteration in the composition of bone. Osteoporotic bones are more at risk of fracture. A chromosomal aberration involving COL1A1 is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF. Belongs to the fibrillar collagen family. |
| UniProt Protein Details: | Protein type:Extracellular matrix; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 10q26 Cellular Component: collagen; collagen type I trimer; cytoplasm; endoplasmic reticulum; extracellular matrix; extracellular region; extracellular space; Golgi apparatus; proteinaceous extracellular matrix; secretory granule Molecular Function:extracellular matrix structural constituent; identical protein binding; metal ion binding; platelet-derived growth factor binding; protease binding; protein binding Biological Process: blood vessel development; collagen biosynthetic process; collagen fibril organization; embryonic skeletal system development; endochondral ossification; extracellular matrix organization; intramembranous ossification; ossification; osteoblast differentiation; positive regulation of cell migration; positive regulation of transcription, DNA-templated; protein transport; response to cAMP; response to corticosteroid stimulus; response to drug; response to estradiol; response to hydrogen peroxide; response to hyperoxia; response to mechanical stimulus; response to nutrient; response to nutrient levels; response to peptide hormone; response to steroid hormone; sensory perception of sound; skeletal morphogenesis; skeletal system development; skin development; skin morphogenesis; visual perception; wound healing |
| NCBI Summary: | extracellular matrix collagen protein [RGD, Feb 2006] |
| UniProt Code: | P02454 |
| NCBI GenInfo Identifier: | 158711704 |
| NCBI Gene ID: | 29393 |
| NCBI Accession: | NP_445756.1 |
| UniProt Secondary Accession: | P02454,P02455, Q63079, A3KNA1, |
| UniProt Related Accession: | P02454 |
| Molecular Weight: | 137,953 Da |
| NCBI Full Name: | collagen alpha-1(I) chain |
| NCBI Synonym Full Names: | collagen type I alpha 1 chain |
| NCBI Official Symbol: | Col1a1Â Â |
| NCBI Official Synonym Symbols: | COLIA1Â Â |
| NCBI Protein Information: | collagen alpha-1(I) chain |
| UniProt Protein Name: | Collagen alpha-1(I) chain |
| UniProt Synonym Protein Names: | Alpha-1 type I collagen |
| UniProt Gene Name: | Col1a1Â Â |
| ELISA Kits |
| Rat Collagen I alpha 1 ELISA Kit |
| Rat Collagen alpha-1(I) chain (Col1a1) ELISA Kit |
| Rat C-telopeptide of Collagen alpha-1(I) chain (CTXI) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
COL1A2/COL1A1 Antibody (PACO07262)
COL1A1 Rabbit Polyclonal Antibody (CAB1352)
COL1A1 Rabbit Polyclonal Antibody (CAB16891)
Mouse COL1A1 / Collagen I ELISA Kit
Rat Collagen Type I Alpha 1 (COL1a1) ELISA Kit
Mouse Collagen Type I Alpha 1 (COL1a1) ELISA Kit
Human Collagen Type I Alpha 1 (COL1a1) ELISA Kit
