The COL19A1 Polyclonal Antibody (PAC023321) is a valuable tool for researchers studying collagen type XIX alpha 1 (COL19A1), a crucial component of the extracellular matrix in various tissues. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the COL19A1 protein, researchers can easily detect and analyze its presence in different cell types, making it an ideal choice for studies in tissue development, wound healing, and fibrosis research.
COL19A1 is known for its role in maintaining tissue integrity and function, particularly in skin, cartilage, and the cornea. Research on COL19A1 is vital for understanding how abnormalities in this protein can lead to diseases like Ehlers-Danlos syndrome, muscular dystrophy, and corneal dystrophies. By studying the function of COL19A1, researchers can uncover new insights into tissue repair mechanisms and potential therapeutic targets for these disorders.
Synthesized peptide derived from internal of human Collagen XIX alpha 1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human thymus gland tissue using Collagen XIX alpha 1 antibody.
Immunofluorescence analysis of A549 cells, using Collagen XIX alpha 1 antibody.
Background:
May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle.
COL19A1: May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 6q12-q13Cellular Component: endoplasmic reticulum lumen; extracellular regionBiological Process: collagen catabolic process; skeletal development
UniProt Protein Details:
NCBI Summary:
This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008]
