The COL19A1 Polyclonal Antibody (PACO07442) is a powerful tool for researchers studying COL19A1, a type XIX collagen protein that plays a key role in extracellular matrix formation and tissue development. This antibody, produced in rabbits, is highly specific for COL19A1 in human samples and has been validated for use in Western blotting applications. By binding to the COL19A1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in the fields of tissue engineering, wound healing, and connective tissue disorders.COL19A1 is a crucial component of the extracellular matrix in various tissues, including skin, cartilage, and blood vessels. Its involvement in collagen fibril assembly and tissue organization underscores its importance in maintaining structural integrity and function.
Research into COL19A1 is essential for understanding the mechanisms underlying tissue development and repair, as well as for investigating potential therapeutic targets for conditions involving abnormal collagen production or organization.The COL19A1 Polyclonal Antibody offers researchers a reliable tool for exploring the role of COL19A1 in physiological and pathological processes, paving the way for advancements in regenerative medicine, biomaterials design, and treatments for connective tissue disorders. By providing a means to accurately detect and study COL19A1 expression, this antibody contributes to the expanding body of knowledge surrounding collagen biology and its impact on human health.
Antibody Name:
COL19A1 Antibody (PACO07442)
Antibody SKU:
PACO07442
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000-1:20000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from human COL19A1. at AA range: 161-210
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of HELA cells using primary antibody diluted at 1:2000(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour).
Synonyms:
Collagen α-1(XIX) chain (Collagen α-1(Y) chain)
UniProt Protein Function:
COL19A1: May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 6q12-q13Cellular Component: endoplasmic reticulum lumen; extracellular regionBiological Process: collagen catabolic process; skeletal development
UniProt Protein Details:
NCBI Summary:
This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008]
