The Collagen XVII Rabbit Monoclonal Antibody (CAB4808) is a cutting-edge tool for researchers studying Collagen XVII, a crucial protein involved in skin integrity and adhesion. This high-quality antibody, produced using rabbit monoclonal technology, offers exceptional specificity and sensitivity for detecting Collagen XVII in various biological samples.Collagen XVII is a transmembrane collagen protein that plays a vital role in maintaining the structural integrity of the skin and other tissues. Dysregulation of Collagen XVII has been implicated in various skin diseases, including blistering disorders and wound healing abnormalities.
The CAB4808 antibody binds specifically to Collagen XVII, enabling accurate detection and analysis in Western blot applications.With its superior performance and reliability, the CAB4808 Collagen XVII Rabbit Monoclonal Antibody is an indispensable tool for research in dermatology, wound healing, and tissue engineering. By facilitating the precise identification and quantification of Collagen XVII, this antibody opens up new possibilities for understanding the pathophysiology of skin disorders and developing targeted therapeutic interventions.
Product Name:
Collagen XVII/COL17A1 Rabbit Monoclonal Antibody
SKU:
CAB4808
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1300-1400 of human Collagen XVII/COL17A1 (Q9UMD9).
Cell junction, Membrane, Secreted, Single-pass type II membrane protein, basement membrane, extracellular matrix, extracellular space, hemidesmosome.
Calculated MW:
150kDa
Observed MW:
150-180kDa
This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.
Purification Method:
Affinity purification
Gene ID:
1308
Clone Number:
ARC0233
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from A-431 cells, using Collagen XVII/COL17A1 Rabbit mAb (CAB4808) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
