The COL11A2 Polyclonal Antibody (CAB10473) is a powerful tool for researchers investigating the COL11A2 protein, which plays a key role in extracellular matrix formation and maintenance, particularly in cartilage and other connective tissues. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting COL11A2 in human samples, making it an excellent choice for Western blot applications.COL11A2 is a critical component of fibrillar collagen that provides structural support and stability to tissues throughout the body. Dysregulation of COL11A2 has been associated with various genetic disorders affecting connective tissue integrity, including Stickler syndrome and Marshall syndrome.
By targeting COL11A2 with this antibody, researchers can gain insights into its function and potential implications for musculoskeletal health and disease.This antibody promises to facilitate accurate and reliable detection of COL11A2 protein in different cell types and tissues, making it an invaluable tool for studies in musculoskeletal biology, tissue engineering, and genetic disorders associated with connective tissue abnormalities. Unlocking the secrets of COL11A2 biology holds great promise for advancing our understanding of connective tissue disorders and developing targeted therapies for these conditions.
Product Name:
COL11A2 Rabbit Polyclonal Antibody
SKU:
CAB10473
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 210-380 of human COL11A2 (NP_542411.2).
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.
Purification Method:
Affinity purification
Gene ID:
1302
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using COL11A2 antibody (CAB10473) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
