The COL11A1 Polyclonal Antibody (CAB10559) is a valuable tool for researchers studying COL11A1, a protein involved in the formation of collagen fibrils in extracellular matrix and connective tissues. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is specifically validated for use in Western blot applications. COL11A1 is a crucial component in maintaining tissue structure and function, particularly in cartilage, bones, and the eye. Abnormalities in COL11A1 expression have been associated with a variety of disorders, including skeletal dysplasias, cleft palate, and ocular diseases.
By targeting COL11A1 with this antibody, researchers can accurately detect and analyze the protein in different cell types, advancing our understanding of its role in development and disease pathology.Furthermore, the COL11A1 Polyclonal Antibody is an essential tool for investigations in developmental biology, orthopedics, and ophthalmology. By uncovering the mechanisms behind COL11A1 function, researchers may identify potential therapeutic targets for conditions affected by aberrant collagen formation.
Product Name:
COL11A1 Rabbit Polyclonal Antibody
SKU:
CAB10559
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 260-430 of human COL11A1 (NP_542196.2).
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
1301
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from A-204 cells, using COL11A1 Rabbit pAb (CAB10559) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
